Body Mass (g)

Body Fat (%)

Baseline

Gonadectomy

Replacement

Baseline

Gonadectomy

Replacement

                     Males

Sham (n=3)

24.0 ± 2.7

23.8 ± 2.9

26.7 ± 4.5

  11.65 ± 1.05

12.19 ± 0.53

11.98 ± 2.48

Testosterone (n=10)

24.1 ± 1.3

24.0 ± 0.7

25.6 ± 1.3

12.63 ± 1.11

12.53 ± 1.56

12.33 ± 0.78

17β-Estradiol (n=9)

24.9 ± 1.1

24.7 ± 1.1

28.2 ± 1.1

13.79 ± 3.47

12.92 ± 1.27

12.36 ± 0.73

                     Females

Sham (n=3)

19.1 ± 0.6

18.5 ± 0.1

20.8 ± 0.5

13.43 ± 0.72

13.84 ± 0.94

12.51 ± 0.39

Testosterone (n=8)

19.7 ± 1.0

21.3 ± 1.2

23.6 ± 1.1

13.46 ± 1.15

12.79 ± 0.79

11.82 ± 0.76

17β-Estradiol (n=8)

18.9 ± 1.0

20.5 ± 1.2

23.4 ± 1.3

14.13 ± 1.86

13.11 ± 1.21

11.14 ± 0.51

Values are mean ± SD.  Baseline data represents normal characteristics, gonadectomy data represents no circulating sex steroids, and replacement represents reintroduced sex steroids.  No significant difference found for the sex by group by treatment interaction.  Individual main effects were reported in the results section.

Table 1: Body mass and % body fat in male and female C57BL/6J mice with altered sex steroid concentrations during wheel running.