Target  

Gene

Vector/Delivery

Immunization

Response

Reference

Brain tumor

IL-12

SFV / Particles

Mouse

Immunogenicity

[93]

Cervical cancer

HPVE6-E7

SFV / Particles

Mouse

Tumor protection

[94]

Glioma

B16, 203

SFV / Particles

Mouse

Tumor protection

[95]

Melanoma

MDA/trp-2

VEE / Particles

Mouse

Therapeutic effect

[42]

Tumor

β-galactosidase

SFV / RNA

Mouse

Tumor protection

[38]

Tumor

HPVE7

VEE / Particles

Mouse

Tumor protection

[40]

Tumor

HPVE6E7+IL12

SFV / Particles

Mouse

Anti-tumor activity

[41]

Tumor

HPVE7-VP22

SIN / Particles

Mouse

CD8+ T-cell response

[96]

Tumor

IL-12

SFV / Particles

Mouse

Tumor protection

[97]

Tumor antigen

MHC class II

SFV / Particles-DNA

Mouse

Immunogenicity

[98]

Tumor antigen

P185

SFV / Particles

Mouse

CTL, tumor protection

[39]

Tumor antigen

trp-1

SIN / DNA

Mouse

Antitumor activity

[99]

CTL: Cytotoxic T-lymphocyte activity; HPV: Human papillomavirus; IL: interleukin; MDA: Melanoma differentiation antigen; MHC: Major histocompatibility complex; SFV: Semliki Forest virus; SIN: Sindbis virus; trp: tyrosine-related protein; VEE: Venezuelan equine encephalitis virus
Table 3: Vaccine development for cancer targets.