Figure 6: Body temperature change among studied groups* of vaccinated ferrets post-challenged with a lethal dose of H5N1 HPAIV; difference from baseline.
*6 animals in group were intranasally immunized with two doses of 7.0 log10 EID50 H5 LAIV candidates 28 days apart, on day 42 challenged with 6.0log10 EID50 of H5N1 HPAIV. Control non immunized animals received placebo. Observation period - 14 days post-challenge.
Groups of ferrets:
1 - immunized with VN/H5N2 LAIV, challenged with A/Vietnam/1194/2004 (H5N1);
2 - immunized with VN/H5N1-RG LAIV, challenged with A/Vietnam/1194/2004 (H5N1);
3 - immunized with t/T/ H5N2 , challenged with A/turkey/Turkey/1/2005 (H5N1)
4 - immunized with Placebo (PBS), challenged with H5N1 A/Vietnam/1194/2004;
5 - immunized with Placebo (PBS), challenged with H5N1 A/turkey/ Turkey/1/2005;
6 - immunized with Placebo (PBS), challenged with Placebo (PBS).