COPD stage Before vaccination After 3 months After 6 months After 12 months unit/ml unit/ml unit/ml unit/ml 1(n=2) 81.45 ± 16.16 158.95 ± 11.6* 139.45 ± 10.05* 133.45 ± 7.65 2(n=21) 73.52 ± 5.43 144.55 ± 10.4*** 136.66 ± 6.23*** 136.21 ± 6.69*** 3 (n=14) 84.25 ± 7.54 158.29 ± 13.9*** 142.77 ± 10.14*** 129.76 ± 9.84*** 4 (n=4) 97.88 ± 18.51 166.65 ± 43.2* 150.2 ± 16.91** 153.73 ± 16.15** Total (n=41) 79.22 ± 4.2 152.41 ± 7.5 *** 140.2 ± 4.9*** 135.58 ± 5.03*** Note: * - р<0.05; ** - p<0.01; *** - p<0.001 – as compared to baseline values.

Table 1: Changes of post-vaccination levels of IgG antibodies to the mixture of polysaccharides comprising Pneumo 23 vaccine in patients with COPD