| Test C (Units) |
0 hour |
|
2 hours |
|
4 hours |
|
8 hours |
|
24 hours |
|
P-values |
Signi-ficance |
Normal |
| 4placebo + 4 Cyclo-Z |
Mean |
SEM |
Mean |
SEM |
Mean |
SEM |
Mean |
SEM |
Mean |
SEM |
|
|
Range |
| Sodium (mmol/L) |
139.78 |
0.3964 |
139.6 |
0.4737 |
138.67 |
0.4019 |
140.22 |
0.8012 |
139.67 |
0.4496 |
0.3402 |
N.S. |
136-146 |
| Potassium (mmol/L) |
4.603 |
0.0778 |
4.525 |
0.0877 |
4.3589 |
0.0746 |
4.2778 |
0.067 |
4.5133 |
0.13 |
0.0875 |
N.S. |
3.5-5.3 |
| Chloride (mmol/L) |
90.62 |
9.138 |
104.7 |
0.5126 |
105.3 |
0.4942 |
104.3 |
0.1306 |
106 |
0.4263 |
0.0537 |
N.S. |
98-106 |
| CO2 (mmol/L) |
30.767 |
0.9025 |
30.6 |
0.3464 |
29.475 |
0.2496 |
29.133 |
0.7535 |
30.667 |
0.7965 |
0.0439 |
N.S |
22-31 |
| Urea Nitrogen (mg/dL) |
10.25 |
0.5789 |
12* |
0.4924 |
9.5 |
0.3371 |
11.0 |
0.3051 |
10 |
0.3051 |
0.01 |
* |
4.0-15.0 |
| Creatinine (mg/dL) |
1.05 |
0.05436 |
2.04 |
0.4743 |
1.025 |
0.04462 |
1.142 |
0.0617 |
1.05 |
0.0544 |
0.98 |
N.S. |
0.5-1.4 |
| EGFR (mL/min) |
94.25 |
3.745 |
90.5 |
7.441 |
96.25 |
6.0 |
86 |
8.768 |
91.25 |
7.779 |
0.8694 |
N.S. |
100-125 |
| Glucose (mg/dL) |
92.5 |
6.865 |
90 |
4.303 |
85.5 |
1.252 |
79.5** |
4.398 |
102.5 |
5.77 |
0.005 |
** |
70-110 |
| Alkaline Phosp. (U/L) |
80.25 |
2.7 |
76.75 |
3.757 |
85.25 |
1.947 |
89 |
2.567 |
81.5 |
3.672 |
0.0577 |
N.S. |
33-94 |
| ALT/WLA (U/L) |
21.5 |
1.098 |
22.25 |
0.9383 |
24.2 |
2.255 |
23.5 |
0.1508 |
22.75 |
0.9624 |
0.4333 |
N.S. |
7.0-45 |
| Bilirubin (mg/dL) |
0.7 |
0.04251 |
0.675 |
0.03286 |
0.65 |
0.05427 |
0.525** |
0.0329 |
0.7 |
0.0564 |
0.0015 |
** |
0.2-1 |
| RBC (M/uL) |
4.765 |
0.03045 |
4.663 |
0.05759 |
4.74 |
0.05518 |
4.6525 |
0.0309 |
4.685 |
0.0519 |
0.2831 |
N.S. |
4.4-5.9 |
| Hemoglobin (g/dL) |
13.93 |
0.1453 |
20.825 |
3.64 |
13.8 |
0.1871 |
13.78 |
0.1924 |
14.275 |
0.167 |
0.0637 |
N.S. |
13.3-17.7 |
| Hematocrit (%) |
41.075 |
0.5118 |
41.325 |
0.5626 |
40.9 |
0.4995 |
40.975 |
0.3951 |
40.85 |
0.1983 |
0.8891 |
N.S. |
39-52 |
| MCV (fL) |
75.58 |
6.353 |
88.525 |
0.2358 |
86.25 |
0.8264 |
88 |
0.3844 |
88.45 |
0.2841 |
0.0566 |
N.S |
80-99 |
| MCH (pg) |
29.225 |
0.223 |
30 |
0.2093 |
29.075 |
0.2847 |
29.625 |
0.223 |
30.4 |
0.2286 |
0.0675 |
N.S. |
27-34 |
| MCHC (g/dL) |
33.95 |
0.1098 |
33.85 |
0.1177 |
33.725 |
0.05789 |
33.675 |
0.1875 |
34.35 |
0.1515 |
0.0758 |
N.S. |
32-36 |
| RDW (%) |
13.725 |
0.2093 |
13.925 |
0.1436 |
13.525 |
0.1303 |
13.825 |
0.1911 |
13.775 |
0.1009 |
0.4953 |
N.S. |
12.0-15.0 |
| PLT (k/uL) |
294.25 |
19.803 |
294.5 |
20.464 |
297 |
20.285 |
311.5 |
21.47 |
295.25 |
20.556 |
0.9715 |
N.S. |
150-440 |
| WBC (k/uL) |
5.325 |
0.4294 |
5.025 |
0.3582 |
5.9 |
0.4848 |
5.875 |
0.5077 |
5.325 |
0.5475 |
0.6201 |
N.S. |
4.5-11 |
| LYMP%-A (%) |
29.85 |
1.948 |
33.475 |
1.382 |
34.2 |
1.357 |
39.3 |
1.398 |
23.2*** |
1.452 |
0.0001 |
*** |
20-40 |
| LYMP#-A (#/uL) |
1525 |
75.001 |
1625 |
32.856 |
1950 |
96.532 |
2225 |
113.57 |
1175*** |
71.904 |
0.0001 |
*** |
600-4800 |
| Monocyte % (%) |
7.9 |
0.3663 |
8.43 |
0.531 |
8.725 |
0.5569 |
7.8 |
0.5204 |
6.425* |
0.5626 |
0.0234 |
* |
2.0-10. |
| Monocyte # (#/uL) |
425 |
39.166 |
326.38 |
64.659 |
525 |
71.904 |
475 |
57.889 |
325 |
44.594 |
0.0801 |
N.S. |
0-950 |
| PMN% (%) |
55.725 |
2.218 |
54.45 |
1.728 |
50.5 |
1.933 |
47.775 |
1.864 |
67.1*** |
1.93 |
0.0001 |
*** |
41-85 |
| PMN# (#/uL) |
2900 |
285.24 |
2800 |
278,8 |
3025 |
324.31 |
2900 |
347.07 |
3650 |
479.83 |
0.4211 |
N.S. |
1100-7700 |
| Eosinophil % (%) |
5.775 |
7.466 |
3.9 |
7.202 |
6.125 |
9.893 |
4.5 |
8.168 |
2.9 |
6.013 |
0.7778 |
N.S. |
1.0-6.0 |
| Eosinophil # (#/ul) |
325 |
49.43 |
200 |
21.32 |
350 |
50 |
250 |
26.112 |
150*** |
15.076 |
0.0009 |
*** |
0-500 |
| Basophil % (%) |
0.75 |
0.1485 |
0.6 |
0.0522 |
0.45 |
0.0151 |
0.625 |
0.0653 |
0.375* |
0.0579 |
0.0159 |
* |
0-1 |
| Basophil # (#/ul) |
25 |
13.056 |
0 |
0 |
0 |
0 |
25 |
13.056 |
0 |
0 |
0.999 |
N.S. |
0-200 |
*P<0.05; **P<0.01; ***P<0.001 (At 0 vs. At 4 or 8 hours) |
