Period

Parameters

Control
X ± SD

4-CPA 10 ppm
X ± SD

4-CPA 20 ppm
X ± SD

SUBACUTE

 

SOD U/g

2170.9 ± 17.0

2170.1 ± 13,5

2148.5 ± 15.2*

GR U/g

2.0 ± 0.1

1.8 ± 0.08*

1.5 ± 0.1*

CAT U/g

191.5 ± 15.3

135.2 ± 17.1*

70.7 ± 11.4*

GSH-Px U/g

276.8 ± 9.6

200.9 ± 8.8*

172.6 ± 9.7*

GST U/g

3.3 ± 0.2

3.1 ± 0.2

3.3 ± 0.1

G6PD U/g

1.0 ± 0.08

1.1 ± 0.06*

0.9 ± 0.08

GSH mg/g

4.8 ± 0.4

6.4 ± 0.6*

3.5 ± 0.2*

MDA nmol/g

38.5 ± 0.6

44.2 ± 1.4*

46.8 ± 3.8*

 

 

 

 

 

SUBCHRONIC

 

SOD U/g

2229.4 ± 15.5

2217.5 ± 18.4

2222.9 ± 16.9

GR U/g

2.4 ± 0.2

2.6 ± 0.4

2.5 ± 0.1

CAT U/g

189.0 ± 16.1

140.1 ± 8.0*

153.5 ± 9.5*

GSH-Px U/g

204.8 ± 7.7

178.0 ± 9.5*

174.7 ± 8.5*

GST U/g

3.4 ± 0.2

3.1 ± 0.3

3.1 ± 0.2

G6PD U/g

1.0± 0.04

1.1 ± 0.01*

1.1 ± 0.02*

GSH mg/g

4.5 ± 0.5

5.9 ± 0.4*

6.3 ± 0.6*

MDA nmol/g

32.5 ± 0.8

49.4 ± 0.3*

53.0 ± 2.4*

Each value represents the Mean ± SD. * p<0.05
Table 8: Effects of 4-CPA 10-20 ppm on antioxidant defence systems and MDA contents in kidney of rats at subacute and subchronic.