Figure 9: Relative concentration comparison of donepezil, M1/M2, M4 and M6 in rat (●,□), mini-pig (▲, ◊) and human (✕,○) after oral (A, C, E, G) or transdermal (B, D, F, H). Solid symbols represent rat and minipig concentrations derived at an early sampling period (Day 1 for rat and mini-pigs administered an oral tablet or Day 29 for mini-pigs administered the transdermal patch) and open symbols are from a later sampling period (Day 86 or 274; for rat and mini-pig, respectively). Concentrations of donepezil and metabolites were quantified from human plasma samples that were selected based upon initially low (✕) and high (○) donepezil concentrations.