Compound/
Metabolited |
MH+a |
RRTb |
Fragment Ions
from CIDc (m/z) |
Proposed transformation from donepezil |
| donepezil |
380 |
1.00 |
362, 288, 273, 243, 205, 189 151, 91 |
NA |
| M1/M2 |
366 |
0.96 |
348, 274, 259, 229,175, 137 91 |
O-demethylation |
| M4 |
290 |
0.89 |
290, 273, 261, 255, 243, 229, 205, 189, 151, 82 |
N-dealkylation |
| M6 |
396 |
1.02 |
378, 288, 273,243, 189, 151, 91 |
N-oxidation |
| M11/12 |
542 |
0.90 |
542, 366 |
O-demethylation/glucuronidation |
| M3 |
396 |
0.95 |
378, 290, 286, 241, 204, 107, 91 |
phenyl hydroxylation |
aMH+: Protonated molecular ion from electrospray ionization.
bRRT: Relative retention time based upon LC method.
cCID: Collision induced dissociation
dNomenclature was taken from Matsui et al. (Matsui K, Mishima M, Nagai Y,
Yuzariha T, and Yoshimura T (1999) Drug Metab Dispos 27: 1406-1414)
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