| Patch |
Number of Tissues |
Time (hr) |
Compound/Metabolite( ng/mL ± SD)a |
|
Donepezil |
M1/M2 |
M6 |
M4 |
M3 |
|
Test Article
|
3 |
1 |
371.6±586.7 |
ND |
ND |
ND |
NA |
|
4 |
619.1±678.2 |
2.1±3.7 |
8.8±15.3 |
10.7±18.6 |
NA |
|
8 |
1038.1±555.1 |
5.9±5.4 |
14.9±22.5 |
20.1±33.0 |
NA |
|
24 |
1720.4±578.1 |
22.6±25.0 |
22.0±29.7 |
42.9±57.4 |
NA |
|
48 |
1860.3±459.0 |
17.0±12.2 |
53.1±26.4 |
114.5±91.7 |
NA |
Note: Mean concentrations of donepezil and its metabolites were estimated using
a single point calibration. ND, Not Detected; NA, detected, quantitative data not
available; aNomenclature was taken from Matsui et al. (Matsui K, Mishima M,
Nagai Y, Yuzariha T, and Yoshimura T (1999) Drug Metab Dispos 27: 1406-
1414) |
