Bacteria

Aa

Tf

Pg

Substrate

Inhibitor

Inducer

Amoxicillin

+

+

++

2C19

Ciprofloxacine

+

1A2, 3A4

2E1

Clindamycine

++

3A4

3A4

Doxycycline

+

3A4

Metronidazole

++

+

2C9, 3A4

2C9, 3A4

Tetracycline

+

+

3A4

Table 2: Effectiveness and CYP metabolism of antibiotic agents used in the therapy of PD. References given in parentheses. “Aa” means Aggregatibacter actinomycetemcomitans, “Tf” Tannerella forsythensis and “Pg” Porphyromonas gingivalis. +: 10-fold increased, ++: 102-fold increased concentration of antibiotic in gingival fluid, expressed in multiples of in-vitro measured minimal inhibitory concentration [32].