Parameter Experimental Calves Mean ± S.E.M.
C1 C2 C3 C4 C5 C6
A1 (mg/ml) 80.16 69.02 79.91 69.30 80.11 80.24 76.45 ± 2.30
A2 (mg/ml) 8.91 8.48 8.75 8.49 8.82 8.80 8.7 ± 0.073
B (mg/ml) 10.44 10.38 10.25 10.40 10.45 10.50 10.40 ± 0.035
β (h-1) 0.11 0.11 0.10 0.12 0.11 0.13 0.11 ± 0.004
α1 (h-1) 11.39 11.39 11.10 11.21 11.4 11.11 11.26 ± 0.058
α2 (h-1) 0.18 0.19 0.20 0.19 0.17 0.20 0.18 ± 0.004
t1/2 α1 (h) 0.060 0.060 0.062 0.061 0.060 0.062 0.060 ± 0.0004
t1/2 α2 (h) 3.85 3.64 3.46 3.64 4.07 3.45 3.99 ± 0.27
t1/2 β (h) 6.3 6.3 6.9 5.77 6.30 5.33 6.15 ± 0.21
AUC(mg/ml.h) 151.43 145.04 153.44 137.52 153.9 131.98 145.55 ± 3.72
AUMC (mg/ml.h2) 1149.04 1093.3 1244.39 957.95 1169.43 841.95 1076.1 ± 60.94
MRT (h) 7.58 7.53 8.10 6.96 7.59 6.37 7.35 ± 0.24
Kel (h-1) 0.65 0.60 0.64 0.64 0.64 0.75 0.65 ± 0.020
T ≈ P 5.25 4.55 4.66 4.55 4.88 4.88 4.96 ± 0.17
Vdarea (L/kg) 0.60 0.62 0.65 0.60 0.59 0.58 0.60 ± 0.010
ClB (L/kg/h) 0.066 0.068 0.065 0.072 0.064 0.075 0.068 ± 0.0017
Table 1: Pharmacokinetic parameters of Amikacin (10 mg/kg, i.v.) and W. somnifera (500 mg/kg,orally) after combined administration in Buffalo calves (n=6).