CP∞ min
(mg/ml) |
τ
(h) |
Dose
(mg/kg) |
Experimental calves |
Mean ± S.E.M. |
C1 |
C2 |
C3 |
C4 |
C5 |
C6 |
1.0 |
8 |
D* |
1.44 |
1.49 |
1.44 |
1.56 |
1.42 |
1.64 |
1.49 ± 0.035 |
D0 |
0.84 |
0.87 |
0.79 |
0.96 |
0.83 |
1.05 |
0.89 ± 0.039 |
12 |
D* |
2.24 |
2.31 |
2.15 |
2.53 |
2.20 |
2.76 |
2.36 ± 0.095 |
D0 |
1.64 |
1.69 |
1.50 |
1.93 |
1.61 |
2.17 |
1.75 ± 0.10 |
2.0 |
8 |
D* |
2.88 |
2.98 |
2.88 |
3.12 |
2.84 |
3.28 |
2.99 ± 0.070 |
D0 |
1.68 |
1.74 |
1.58 |
1.92 |
1.66 |
2.1 |
1.78 ± 0.079 |
12 |
D* |
4.48 |
4.62 |
4.3 |
4.06 |
4.4 |
5.52 |
4.733 ± 0.19 |
D0 |
3.28 |
3.38 |
3.0 |
3.86 |
3.22 |
4.34 |
3.51 ± 0.20 |
Where,
D*=Priming or Loading dose,
D0=Maintenance dose
τ =Dosage interval,
CP∞ min=Minimum therapeutic concentration in plasma |