| |
Iron isomaltoside 1000 IV bolus doses |
| 100 mg |
200 mg |
500 mg |
| Mean (SD) |
Geometric mean |
Mean (SD) |
Geometric mean |
Mean (SD) |
Geometric mean |
| AUC0-t (mg h/dL) |
3.21 (1.17) |
2.99 |
6.73 (2.48) |
6.26 |
14.80(3.99) |
14.34 |
| AUC (mg h/dL) |
4.69 (2.74) |
4.00 |
9.44 (4.50) |
8.54 |
19.51 (6.92) |
18.61 |
| Cmax(mcg/dL) |
101(23) |
99 |
210 (60) |
202 |
507 (175) |
484 |
| Tmax (h) |
1.42 (1.39) |
1.00 |
1.35 (1.43) |
0.91 |
0.59 (0.22) |
0.57 |
| Ke (1/h) |
0.0273 (0.0144) |
0.0240 |
0.0266 (0.0186) |
0.0226 |
0.0230 (0.0058) |
0.0223 |
| T1/2 (h) |
33.07 (18.99) |
28.86 |
35.14 (18.10) |
30.72 |
32.35 (10.68) |
31.14 |
|
