Key cluster

EASE-score

Sub-cluster

P-value (Benjamini)

Transcription binding

3.25

Transcription factor binding

3.0E-2

 

 

Transcription cofactor activity

6.1E-2

Apoptosis

2.29

Regulation of apoptosis

2.8E-1

 

 

Cell development

6.8E-1

 

 

Cell differentiation

9.9E-1

Cellular stress

0.56

Response to stress

1.0E-2

 

 

Response to wounding

9.9E-1

 

 

Response to external stimulus

5.2E-1

 

 

Defense response

9.3E-1

 

 

Inflammatory response

9.7E-1

Cell cycle

3.15

Regulation of cell cycle

2.9E-2

Intracellular transport

3.31

Golgi vesicle transport

6.3E-3

 

 

ER to Golgi vesicle-mediated transport

3.0E-2

Biotic stimulus

1.5

Response to biotic stimulus

5.2E-1

Tissue healing

None

Wound healing

-

 

 

Hemostasis

-

 

 

Blood coagulation

-

 

 

Regulation of body fluid levels

-

 

 

Platelet activation

-

 

 

Complement and coagulation cascades

-

Table 4: Key- and sub-clusters of genes associated to the ongoing posttraumatic inflammation or bone regeneration. The genes are differentially expressed at day 1 and day 42 in patients with hip fractures.