Overall Survival

Progression-Free-Survival

Variables

     HR          95%CI           P-value

     HR          95%CI        P-value

Age > 60 years

   1.020   1.002-1.032     <0.03

   1.013    1.001-1.127      0.06

Age-R > 60 years

   1.291   0.775-1.531       0.2

   1.010    0.998-1.024      0.09

LDH

   1.994   1.501-3.451     <0.0001

   1.786    1.560-2.264    <0.0005

LDH-R

   2.461   1.711-2.910     <0.0001

   1.996    1.501-2.183    <0.0001

Extra-nodal sites > 1

   1.027   0.988-1.433       0.1

   1.416    0.866-2.391      0.2

Extra nodal sites-R >1

   1.981 1.176-2.590 <0.004

  1.951 1.325-2.441 <0.006

PS > 1

   1.644   0.943-2.313       0.3

   1.888    0.987-2.231      0.1

PS-R > 1

   2.280   1.438-2.742     <0.0001

   2.111    1.473-2.735    <0.002

Stage III/IV

   1.207   0.828-1.935       0.3

   1.230    0.930-1.813      0.3

Stage-R III/IV

   2.067  1.819-2.483      <0.0001

   1.997    1.501-2.741   <0.0001

IPI ≥ 2

   1.748   1.298-2.280     <0.002

   1.810    1.552-2.030    <0.0005

IPI-R > 2

   2.618   2.382-3.091     <0.0001

   2.258    1.942-2.407    <0.0001

CR prior to transplant

   0.119-0.644 <0.0003

   0.449    0.223-0.631    <0.0001

ALC-15 (continuous variable)

   0.155   0.081-0.282     <0.0001

   0.209    0.116-0.360    <0.0001

ALC -15≥ 500 cells/µl

   0.252   0.196-0.498     <0.0001

   0.288   0.221-0.448     <0.0001

AMC-15 (continuous variable)

   2.001   1.489-2.646     <0.0001

   2.059   1.541-2.694     <0.0001

AMC-15 ≥ 600 cell/µl

  1.261    1.101-2.383     <0.0001

   1.315   1.191-2.400     <0.0001

ALC/AMC-15 ratio (continuous variable)

  0.100    0.073-0.400     <0.0001

   0.117   0.053-0.292     <0.0001

ALC/AMC-15 ratio ≥ 1

  0.376    0.273-0.506      <0.0001

   0.412  0.317-0.548      <0.0001

ANC-15

  0.846    0.735-0.960       <0.009

   0.873  0.771-0.978      <0.02

Plts-15

  0.991    0.986-0.997       <0.0002

   0.993  0.987-0.997      <0.0006

Pre-transplant Rituximab (yes)

  0.501    0.170-0.812      <0.0001

   0.560  0.259-0.786      <0.0001

Abbreviations: Age-R = age at relapse; Extranodal sites-R = extranodal sites at relapse; LDH = lactate dehydrogenase; LDH-R = lactate dehydrogenase at relapse; PS = performance status; PS-R = performance status at relapse; stage-r = stage at relapse; IPI = International Prognostic Index; IPI-R = International Prognostic Index at relapse; CR = complete remission; PR = partial response; ALC = absolute lymphocyte count; ANC-15 = absolute neutrophil count at day 15; AMC = absolute monocyte count; and plts-15 = platelets at day 15
Table 3: Univariate analysis for Overall Survival and Progression-Free Survival.