Origin Species hepatic transcription
factor genes
ref
ESCs mouse FOXA2 [27]
ESCs mouse FOXA2 [28]
ESCs mouse E-cadherin [62]
ESCs mouse HEX [38]
ESCs human SOX17 [24]
ESCs/iPSCs human SOX17 [25]
ESCs/iPSCs human HNF4α [60]
ESCs/iPSCs human HEX [39]
hepatic progenitor cells
isolated from E14 fetal
mouse
mouse HNF4α [63]
lineage-depleted OsM
receptor β expressing
bone marrow cells
mouse HNF4α [64]
human unbilical cord
mesenchymal stem cells
human hTERT [64]
human mesenchymal
stem cells
human HNF4α [65]
adult liver derived
progenitor cells
mouse FOXA2, HNF4α, c/EBPα [61]
fibroblasts mouse HNF4α, FOXA1-3 [66]
fibroblasts mouse GATA4, HNF1α, FOXA3 (+
inactivation of p19Arf)
[67]
Table 1: Strategies for in vitro hepatic differentiation by using hepatic transcription factor genes.