Year

Authors

Disease

Sample

Inflammatory Findings

2005

Alexander et al.

Complex Regional Pain Syndromes

Cerebral Spinal Fluid

Increased IL-6 and IL-1β

2007

Uceyler, et al.

Complex Regional Pain Syndromes

Serum

Increased IL-2 and TNF-α. Decreased anti-inflammatory IL-4 and IL-10

2009

Doupis, et al.

Painful Diabetic Peripheral Neuropathy

Serum

Higher levels of TNF-α in painful versus painless diabetic peripheral neuropathy

2009

Lee, et al.

Degenerative Disc Disease

Intervertebral Disc

Higher levels of TNF-α and IL-8

2010

Kraychete, et al.

Herniated Disc

Serum

Greater levels of IL-6 and TNF-α

2010

Cuellar, et al.

Degenerative Disc Disease

Disc Fluid

Increased IFN-gamma

2010

Kim, et al.

Osteoarthritis

Cartilage

TNF-α and IL-1β caused more damage to mitochondria of OA tissue than normal tissue

2011

Levinger, et al.

Osteoarthritis

Muscle

Higher levels of IL-6, IL-1β, and TNF-α

2011

Purwata, et al.

Painful Diabetic Peripheral Neuropathy

Serum

Higher levels of   TNF-α

2011

Orita, et al.

Osteoarthritis

Synovial Fluid

Higher levels of IL-6 and TNF-α

IL=interleukin, TNF=tumor necrosis factor
Table 2: Human Studies and Inflammation.