Cohort

Early menarche*

Regular menses

Cycle length (days)

 

    Yes  No  Yes  No  <24  25-30  31-35  ≥ 36

Maternal
characteristics

 N=(3461)  N=(506)  N=(2955)  N=(2951)  N=(504)  N=(166)  N=(2534)  N=(479)  N=(282)

Age(years)*

 32.7
± 4.5		 32.0
± 4.9		 32.8
± 4.4		 32.7
± 4.5		 32.8
± 4.5		 31.8
± 4.6		 33.0
± 4.6		 32.7
± 4.1		 31.8
± 3.9
     <25 127
(3.7)		 37
(7.3)		 90
(3.0)		 13
(2.6)		 114
(3.9)		 8
(4.8)		 101
(4.0)		 8 (1.7) 10
(3.5)
     25-34  2151
(62.1) 		 312
(61.7) 		 1839
(62.2) 		 312
(62.9) 		 1834
(62.1) 		 107
(64.5) 		 1515
 (59.8) 		 329
(68.7) 		 200
(70.9)
    ≥35  1183
(34.2) 		 157
(31.0) 		 1026
 (34.7) 		 179
 (35.5) 		  1003
(34.0) 		 51
(30.7) 		 918
 (36.2) 		 142
(29.6) 		 72
 (25.5)

NH Whitea

 3000
(86.9) 		 395
(78.4) 		 26.0
(88.2) ¥ 		 2564
(86.9) 		 431
(85.5) 		 148
 (89.2) 		 2195
(86.7) 		 416
(86.5) 		 241
(85.8) ¥

High school
completed

 3327
(96.1) 		 474
 (93.7) 		 2853
(96.5) ¥ 		 2837
 (96.1) 		 484
(96.0) 		 156
(93.9) 		 2426
 (95.7) 		 475
(99.2) 		 270
(95.7) ¥

Married

 3162
(91.4) 		 448
(88.5) 		 2714
(91.8) ¥ 		 2694
 (91.3) 		 462
(91.7) 		 151
(90.9) 		 2292
 (90.4) 		 461
(96.2) 		 258
(91.5) ¥

Nulliparous

 2175
(62.8) 		 314
(62.1) 		 1861
(62.9) 		 1858
(62.9) 		 315
(62.5) 		 103
 (62.0) 		 1593
(62.9) 		 297
(62.0) 		 182
(64.5)

BMI at age 18, kg/m2**‡

  20.7
± 2.9 		 21.77
± 3.6 		 20.5
± 2.79¥		  20.7
± 2.9 		 20.7
± 2.7 		 20.5
± 2.8 		 20.7
± 2.9 		 20.4
± 2.6 		 20.9
± 3.6
     <18.5  2569
(75.4) 		 374
(75.4) 		 2195
(75.4) 		 2184
(75.1) 		 381
(76.7) 		 121
(74.7) 		 1884
 (75.5) 		 360
(76.3) 		 204
 (73.1)
     18.5-24.9  616
 (18.1) 		 56
 (11.3) 		 560
(19.2) 		 527
(18.1) 		 87
(17.5) 		34
(20.1) 		 436
(17.7) 		89
 (18.9) 		 57
(20.4)
Table 1 Continued.                  

 

Cohort

Early menarche*

Regular menses

Cycle length (days)

 

    Yes  No  Yes  No  <24  25-30  31-35  ≥ 36

Maternal
characteristics

 N=(3461)  N=(506)  N=(2955)  N=(2951)  N=(504)  N=(166)  N=(2534)  N=(479)  N=(282)
     25-29.9  170
(4.9) 		 45
(9.1) 		 125
(4.3) 		 146
(5.0) 		 24
 (4.8) 		5
(3.1) 		 136
(5.4) 		 20
(4.2) 		 9
(3.2)
     ≥30  53
(1.6) 		 21
(4.2) 		 32
(1.1) 		 48
(1.6) 		 5
(1.0) 		 2
 (1.2) 		 39
(1.6) 		 3
(0.6) 		 9
(3.2)

Physically
active ***

  3248
(93.8) 		 473
(93.5) 		 2775
(93.9) 		 2768
(93.8) 		 474
 (94.0) 		 156
 (93.9) 		 2369
 (93.4) 		 456
 (95.2) 		 267
 (94.7)

History of
hypertension

 170
(4.9) 		 29
(5.7) 		 141
(4.7) 		 149
(5.0) 		 20
(4.0) 		 9
(5.4) 		 121
(4.8) 		 27
(5.6) 		 13
(4.6)

History of
diabetes mellitus

 44
(1.3) 		 13
(2.6) 		 31
 (1.0) ¥ 		 39
(1.3) 		 4
(0.8) 		 1
(0.6) 		 34
(1.3) 		 4
(0.8) 		 5
(1.8)

Never smoker

 2494
 (72.3) 		 355
(70.4) 		 2139
 (72.7) 		 2123
 (72.2) 		 367
(73.0) 		 116
 (69.9) 		 1796
(71.2) 		 364
(76.3) 		 218
(77.6)

Adult onset asthma

 261
(7.5) 		 55
(10.9) 		 206
(6.9) ¥ 		 219
(7.4) 		 36
(7.1) 		 10
(6.0) 		 193
(7.6) 		 34
(7.1) 		 24
(8.5)

*Early menarche age <12years       ** Mean (SD) otherwise n (%).‡ Body mass index  (kg/m2)*        ***Between age 13 -17 years      ¥ p-value <0.05
aNH – Non-Hispanic
Table 1: Selected characteristics of the study population by age at menarche and menstrual characteristics.