Figure 1: Pie-chart of classified differentally regulated genes (DRGs) either down- (upper panel) or up-regulated (lower panel) in Hoxa10-/- according to the biological functions of the gene products. 237 and 101 genes are downor up-regulated more than 2-fold in Hoxa10-/- vs. control tissues at 4.5 dpc. Among the genes whose expression is repressed in Hoxa10-/-, about a quarter are those encoding structural proteins or involved in differentiation; another quarter encode proteins found in metabolic pathways. The majority of genes upregulated in Hoxa10-/- are involved in immune response.