Table 1

GPCR		no. of analyzed ligands	range for ΔH^o(p,T_o) [kJ/mol]	range for -TΔS^o(p,T_o) [kJ/mol]	ref.
βRs	agonists	13	-143 to -17	-8 to 93	[23]
βRs	antagonists	15	-21 to 16	-53 to -16	[23]
hH₁R	agonists	14	-37.6 to 25.6	-59.6 to 5.8	[13]
hH₁R	antagonists	10	-1.5 to 80.2	-120.7 to -42.4	[13]
gpH₁R	agonists	16	-24.1 to 41.8	-77.4 to -6.8	[13]
gpH₁R	antagonists	8	1.0 to 98.8	-145.9 to -49.2	[13]
gpH₃R	agonists	7	6.4 to 44.5 (buffer A), -9.2 to 15.1 (buffer A_Ca)	-92.0 to -58.3 (buffer A), -60.7 to -38.1 (buffer A_Ca)	[14]
gpH₃R	antagonists	3	-34.1 to -22.9 (buffer A), -40.7 to -10.5 (buffer A_Ca)	-35.1 to -16.9 (buffer A), -43.8 to -10.3 (buffer A_Ca)	[14]
D₂R	agonists	11	-224 to 90	-136 to 176	[23]
D₂R	antagonists	22	-89 to 59	-105 to 107	[23]
sheep D₂R	agonists	1	90.0 (high affinity); 54.4 (low affinity)	-136.0 (high affinity); -91.1 (low affinity)	[12]
sheep D₂R	antagonists	3	14.6 to 58.6	-107.3 to -72.4	[12]
r5-HT_1AR	agonists	8	-65 to 58	-109 to 20	[10]
r5-HT_1AR	antagonists	7	15 to 80	-109 to -47	[10]
hCB₁R	agonists	5	17 to 59	-108 to -64	[21]
hCB₁R	antagonists	3	-52 to -26	-11 to 4	[21]
hCB₂R	agonists	5	27 to 48	-89 to -70	[21]
hCB₂R	antagonists	3	-19 to -17	-22 to -13	[21]
A₁R	agonists	6	19 to 46	-106 to -61	[18]
A₁R	antagonists	6	-37 to -20	-18 to 7	[18]
A₂AR	agonists	6	7 to 50	-83 to -53	[18]
A₂AR	antagonists	6	-45 to -7	-28 to -4	[18]
A₂BR	agonists	6	7 to 23	-65 to -37	[18]
A₂BR	antagonists	6	-40 to -20	-27 to -3	[18]
A₃R	agonists	6	21 to 67	-122 to -67	[18]
A₃R	antagonists	5	-52 to -9	-24 to -5	[18]

Table 1: Summary of thermodynamics studies, addressing GPCRs. This table gives a summary of most important data, available in literature. However, within this table, different assay conditions or species for data regarding one distinct receptor are not taken into account in all cases. For detailed information, it is referred to the mentioned references.