| compound |
Inhibition % of edema Volume of edema (ml)b and %AIc |
| 1 h |
2 h |
3 h |
4 h |
| ref |
0.33c ± 0.12 |
2.18de ± 0.45 |
2.30d ± 0.96 |
2.60e ± 2.21 |
| Indomethacin |
0.34 ± 0.02** (31)c |
0.38 ± 0.07** (59) |
0.42 ± 0.09** (65) |
0.48 ± 0.05** (79) |
| 3 |
4.72c ± 0.08>**
(30)c |
21.86c ± 0.86**
(45)c |
33.69c ± 1.24**
(57)c |
47.73c ± 2.21**
(63)c |
| 4 |
1.25d ± 0.03**
(33)c |
15.28bc ± 1.02**
(42)c |
21.01e ± 0.75**
(55)c |
38.26 e ± 0.93**
(62)c |
| 5 |
6.27c ± 0.21**
(35)c |
16.64b ± 1.55**
(48)c |
26.07d ± 1.04**
(56)c |
42.24d ± 1.08**
(61)c |
| 6 |
5.47a ± 3.25**
(39)c |
13.63a ± 3.57**
(56)c |
18.26a ± 4.52**
(54)c |
43.05a ± 3.67**
(77)c |
| 8a |
9.15b ± 2.42**
(32)c |
11.15a ± 4.25**
(51)c |
24.78b ± 2.65**
(65)c |
36.24a ± 4.22**
(78)c |
| 8b |
3.32e ± 0.01**
(31)c |
12.58e ± 0.22**
(59)c |
25.87e ± 0.88**
(63)c |
35.71e ± 1.35**
(78)c |
| 8c |
2.37e ± 0.01**
(25)c |
13.01d ± 0.85**
(50)c |
26.50d ±1.24**
(62)c |
36.32b ± 2.52**
(78)c |
| 8d |
2.15b ± 2.42**
(33)c |
13.15a ± 4.25**
(51)c |
25.78b ± 2.65**
(69)c |
37.24a ± 4.22**
(78)c |
| LSD at 5% |
5.50 |
4.12 |
4.53 |
3.58 |
|
aDose levels: test compounds (50 mg/kg body wt.), indomethacin (10 mg/kg body wt.)
bValues are expressed as mean ± SEM and analyzed by ANOVA
cValues in parentheses (percentage anti-inflammatory activity, AI%)
*Significantly different compared to respective control values, P<0.05
**Significantly different compared to respective control values, P<0.01 |
| Table 1: Inhibitory effect in vivo anti-inflammatory activity of compounds 3, 4, 5, 6, 8 and Indomethacin on carrageenan- induced edema of the hind paw in rats. |
