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Figure 1: The cancer “avalanche” model of CRCs regulated epigenetic land scape. a. Representative GEDI maps of stem-like attractos, progenitor/intermediate attractors and differentiation attractions. b. (Left panel) An illustration of hierarchy within an epigenetic landscape for a single transition pathway frow stem cell (top) to final cell type (bottom). (Right panel) Deregulation and modification of the epigenetic landscape as a consequence of defective CRCs regulated epigenetic landscape. |