Figure 1: The cancer “avalanche” model of CRCs regulated epigenetic land scape.
a. Representative GEDI maps of stem-like attractos, progenitor/intermediate attractors and differentiation attractions.
b. (Left panel) An illustration of hierarchy within an epigenetic landscape for a single transition pathway frow stem cell (top) to final cell type (bottom). (Right panel)
Deregulation and modification of the epigenetic landscape as a consequence of defective CRCs regulated epigenetic landscape.