Table 1

Name	Resolution	Theoretical coverage	Epigenetic mark	Applications
WGBS	Single nucleotide resolution	Whole genome	DNA methylation	Accurate measurement of genome-wide DNA methylation
MeDIP-Seq	High resolution	Highly methylated and high CpG density regions	DNA methylation	Rapid and large scale study of DNA methylation
RRBS	Single nucleotide resolution	CpG-rich regions	DNA methylation	Accurate DNA methylation study of targeted CpG-rich regions
ChIP-Seq	High resolution	Global binding sites of histones or transcriptional factors	Histone modification, transcriptional factors	Genome-wide study of histone modifications and transcriptional factors

The full names of NGS-based methods are represented as follows. Whole genome bisulfite sequencing (WGBS), Methylated DNA immunoprecipitation sequencing (MeDIP-Seq), Reduced representation bisulfite sequencing (RRBS) and chromatin immunoprecipitation sequencing (ChIP-Seq).

Table 1: Four NGS-based methods to identify DNA methylation and histone modifications.