Study |
Country |
Criteria |
Genotyping methods |
AD |
Control |
N (% Female) |
Mean age |
N (% Female) |
Mean age |
Beyer [12] |
Spain |
DSM-IV; NINCDS-ADRDA |
RFLP |
172(62%) |
70.8 |
166 (60%) |
68.7 |
Bosco [13] |
Italy |
CERAD |
RFLP |
152 (54%) |
74.8 |
136 (55%) |
69.3 |
Dorszewska [15] |
Poland |
NINCDS-ADRDA |
RFLP |
38(61%) |
66.3 ± 12.2 |
50 (68%) |
44.6 ± 16.2 |
Giedraitis [18] |
Sweden (ULSAM) |
NINCDS-ADRDA; DSM-IV |
high and ultra-high throughput genotyping |
86 (0%) |
80.2(AAO) |
404 (0%) |
81.8 |
Li [17] |
Canada |
NINCDS-ADRDA |
GWAS |
753 (58%) |
77.8 ±8.6 |
736 (64%) |
73.4 ± 7.9 |
Linnebank [14] |
Germany |
DSM-IV |
RFLP |
162 (68%) |
72 ±9 |
169 (56%) |
71 ± 7 |
Reiman [16] |
USA, Netherlands |
NM |
GWAS |
861 (-) |
74.9 ± 6.6 |
550 (-) |
77.4 ± 7.3 |
Zhao [19] |
China |
DSM-IV; NINCDS-ADRDA |
RFLP |
353 (52%) |
68.9 ± 9.2 (AAO) |
346 (47%) |
68.5 ± 9.1 |
Coppede [20] |
Italy |
DSM-IV; NINCDS-ADRDA |
RFLP |
375(63%) |
74.2±6.46 |
307(63%) |
71.7±8.02 |
Note: ULSAM, Uppsala Longitudinal Study of Adult Men; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders IV; NINCDS-ADRDA, the National Institute of
Neurological and Communicative Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association; CERAD, the Consortium to Establish a Registry for
Alzheimer’s Disease .NM, Not mentioned; RFLP, restriction fragment length polymorphism; GWAS, genome-wide association study; AAO, Age at onset |
