Groups Parameters Glycogen (mg/g tissue) Glycogen phosphorylase (mU/100mg tissue) Glucose-6-phosphatase (mU/100mg tissue) Glucokinase (mU/100mg tissue) Normal control 8.20±0.32a 14.15±1.14b 28.04±1.01b 50.93±6.09a Diabetic control 4.63±0.39c 29.36±3.29a 32.89±1.53a 56.89±8.49a Diabetic treated with 4b 6.74±0.41b 12.79±1.04b 28.97±1.21b 63.65±8.96a F-probability P<0.001 P<0.001 P<0.05 P>0.05 LSD at the 5% level 1.14 6.32 3.82 - LSD at the 1% level 1.58 8.74 5.29 -

Table 7: Effect of pyrimido[1,6-a]quinazoline derivative 4b on liver glycogen content and glycogen phosphorylase, glucose-6-phosphatase and hexokinase activities in n5-STZ induced type 2 diabetic female rats.