| Simvastatin/Grapfruit juice/day |
C max |
AUC |
| W/G-Active |
W/G-Total |
W/G-Active |
W/G-Total |
| Inhibitors* |
Inhibitors* |
| ng-eq/ml** (p) |
ng-eq/ml **(p) |
| 60mg/1200m (3) |
21.0/ 26.8 |
86.7/ 159 |
88.0/ 213 |
243/ 862 |
| ( p<0.05) |
(p<0.01) |
( p<0.01 ) |
5mg/ 400ml (present
series) |
1.9/ 2.7 |
7.1/ 8.5 |
8.7/ 14.5 |
22.9/ 38.2 |
| ( NS ) |
(p=0.024) |
(p=0.002) |
|
| W: water group, G: grapefruit juice group, Active Inhibitors*: active HMG-CoA reductase inhibitors, Total Inhibitors*: total HMG-CoA reductase inhibitors Ng-eq/m l** refers to the nanogram equivalents of simvastatin acid |
| Table 3: Review of the literature measuring HMG-CoA reductase inhibitors level with regard to interaction of grapefruit juice with simvastatin. |