Parameter Control group (Group I) (n=20) Group II (50 benign breast tumor patients) Group III (77 malignant breast tumor patients)
Non-metastatic (Group III a) Metastatic (Group III b)
Erythrocyte MDA (μmol/ml packed RBCs) 7.11 ± 1.07 10.8 ± 2.49 (a) 14.70 ±0.885 (a) 21 ± 2.72 (a, c)
18.00 ± 3.81 (a, b)
Plasma MDA (nmol/ml) 0.59 ± 0.11 0.88 ± 0.22 (a) 1.26 ± 0.08 (a) 1.59 ± 0.19 (a, c)
1.44 ± 0.22 (a, b)
SOD (%) 58.86 ± 3.44 49.79 ± 4.71 (a) 24.36 ± 1.8 (a) 19.61 ± 4.68 (a, c)
21.41 ± 4.52 (a, b)
CAT ( μmol/SEC/ml) 0.73 ± 0.09 0.58 ± 0.09 (a) 0.41 ± 0.05 (a) 0.31 ± 0.06 (a, c)
0.36 ± 0.07 (a, b)
GSH (mmol/L) 1667.8 ± 176.3 1526.8 ± 141.1 (a) 1150.6 ± 242.4 (a) 956.4 ± 206.3 (a, c)
1053.62 ± 240.61 (a,b)
GST ( μmol/min/ml) 3.59 ± 0.22 2.94 ± 0.81 (a) 2.71 ± 0.42 (a) 2.39 ± 0.27 (a, c)
2.53 ± 0.38 (a,b)
Nitric oxide ( μmol/L) 11.85 ± 2.2 15.51 ± 1.85 (a) 18.78 ± 1.31 (a) 20.59 ± 2.38 (a, c)
19.94 ± 2.42 (a, b)
MDA (malondialdehyde), SOD (superoxide dismutase), CAT (catalase), GSH (reduced glutathione), GST (glutathione-S-transferase) a) Significant against control group; b) Significant against benign group; c) Significant against non-metastatic cancer group; (Significant at P ≤ 0.05)
Table 2: Levels of different oxidative parameters measured in the study groups (mean ± SD) in relation to the control group.