Hospital 1 Hospital 1 AUC (mg.h/L) Dose adjustment (n=105) Maintained dose (n=83) Dose adjustment (n=59) Maintained Dose (n=34)   >100 4.8% 7.2% 3% 8.5%   70-100 49.5% 45.8% 44% 42.4%   <70 45.7% 47% 53% 49.1%

Table 2: Percentage of AUCs below, within and above the therapeutic range after a dose-adjustment (initial and maintenance).