Table 3

All reported cyclosporine concentrations (n=522)
Groups	Range	Mean ± SD
K_e (hr^-1)	0.03-0.9 (hr^-1)	0.159 ± 0.061 (hr^-1)
t_1/2 (hr)	0.77- 83.8 (hr)	5.1 ± 3.87 (hr)
V/F (L)	22.23-1819.7 (L)	129.79 ± 96.67 (L)
CL/F (L/hr)	5.15-48.93 (L/hr)	17.85 ± 5.9 (L/hr)
AUC (ng/ml/hr)	2348.5-14915.9 (ng/ml/hr)	9907.2 ± 818.23 (ng/ml/hr)
c₀: (ng/mL)	16-959.1 (ng/ml)	180.7 ± 112.6 (ng/ml)
c₂: (ng/mL)	110-1887.7 (ng/ml)	789.2 ± 355.6 (ng/ml)
Toxic cyclosporine concentrations (Trough level >300 ng/dl /Peak level>1000 ng/dl) (n=57)
Groups	Range	Mean ± SD
K_e (hr^-1)	0.06-0.17 (hr^-1)	0.08 ± 0.035 (hr^-1)*
t_1/2 (hr)	12.8- 83.8 (hr)	10.6 ± 7.34 (hr)**
V/F (L)	72.6-1819.7 (L)	260.29 ± 243.4 (L)*
CL/F (L/hr)	7.59-35.41 (L/hr)	18.66 ± 5.7 (L/hr)
AUC (ng/ml/hr)	5429.27-13575.6 (ng/ml/hr)	9836.1 ± 1010.61 (ng/ml/hr)
c₀: (ng/mL)	301.1-959.1 (ng/ml)	439.9 ± 232.7 (ng/ml)
c₂: (ng/mL)	725.2-1887.7 (ng/ml)	1007.6 ± 288.4 (ng/ml)
High normal cyclosporine concentration (Trough level 200-300ng/dl/Peak level 900-1000ng/dl) (n=125)
Groups	Range	Mean ± SD
K_e (hr^-1)	0.03-0.8 (hr^-1)	0.18 ± 0.19 (hr^-1)
t_1/2 (hr)	3.05-24.46(hr)	5.7 ± 1.9 (hr^-1)
V/F (L)	44.39-441.22 (L/hr)	146.1 ± 62.5(L/hr)
CL/F (L/hr)	7.37-35.91 (L/hr)	17.96 ± 5.6 (L/hr)
AUC (ng/ml/hr)	8133.33-12192.9 (ng/ml/hr)	9933.42 ± 411.23 (ng/ml/hr)
c₀: (ng/mL)	200.5-298.2 (ng/ml)	243.13 ± 28.8 (ng/ml)
c₂: (ng/mL)	783.69-1767.6 (ng/ml)	912.1 ± 263.3 (ng/ml)
Normal cyclosporine concentration (Trough level 150-200/dl/Peak level 800-900 ng/dl) (n=151)
Groups	Range	Mean ± SD
K_e (hr^-1)	0.03 -1.3 (hr^-1)	0.21 ± 0.2 (hr^-1)
t_1/2 (hr)	3.31-21.65(hr)	4.9 ± 1.93 (hr^-1)
V/F (L)	45.23-309.32 (L/hr)	125.27 ± 51.27(L/hr)
CL/F (L/hr)	7.17-34.46 (L/hr)	18.02 ± 6.1(L/hr)
AUC (ng/ml/hr)	5437.4-1083902 (ng/ml/hr)	9932.42 ± 448.94 (ng/ml/hr)
c₀:(ng/mL)	150.0-199.7.2 (ng/ml)	174.77 ± 15.38 (ng/ml)
c₂: (ng/mL)	411.1-1328.2(ng/ml)	783.8 ± 183.5 (ng/ml)

K_e: Elimination constant V: Volume of distribution F: Bioavailability CL: Clearance AUC: Area Under the Curve C₀:Cyclosporine trough level C₂:Cyclosporine peak level *P<0.05% **P ≤ 0.01%

Table 3: Pharmacokinetic or toxicokinetic sort of parameters under patients with renal transplanted for the diversified concentration of cyclosporine.