| Parameter |
Group I |
Group II |
Group III |
Group IV |
Group V |
Group VI |
Group VII |
| 1 month |
2-4 month |
4-6 month |
6-8 month |
8-10 month |
10-12 month |
>12 month |
| All reported cyclosporine concentrations (n=522) |
| No Signs of Toxicity |
75 |
68 |
72 |
44 |
60 |
50 |
56 |
| Hypertension |
11 |
12 |
9 |
12 |
6 |
8 |
8 |
| Tremors |
1 |
2 |
ـــــ |
2 |
1 |
ـــــ |
2 |
| Facial Flushing |
ـــــ |
1 |
3 |
2 |
1 |
ـــــ |
1 |
| Over growth of gums |
ـــــ |
ـــــ |
ـــــ |
1 |
3 |
ـــــ |
1 |
| Hirsutism |
ـــــ |
ـــــ |
1 |
ـــــ |
ـــــ |
1 |
ـــــ |
| Visual Impairment |
ـــــ |
ـــــ |
2 |
2 |
ـــــ |
2 |
ـــــ |
| Toxic cyclosporine concentrations (Trough level >300 ng/dl and or Peak level >1000 ng/dl) (n=57) |
| No Signs of Toxicity |
5 |
4 |
2 |
ـــــ |
ـــــ |
1 |
ـــــ |
| Hypertension |
7 |
6 |
7 |
7 |
4 |
6 |
3 |
| Tremors |
ـــــ |
1 |
ـــــ |
2 |
1 |
ـــــ |
1 |
| Facial Flushing |
ـــــ |
ـــــ |
3 |
1 |
ـــــ |
ـــــ |
1 |
| Over growth of gums |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
3 |
ـــــ |
1 |
| Hirsutism |
ـــــ |
ـــــ |
1 |
ـــــ |
ـــــ |
1 |
ـــــ |
| Visual Impairment |
ـــــ |
ـــــ |
2 |
2 |
ـــــ |
1 |
ـــــ |
| High normal cyclosporine concentration (Trough level 200-300 ng/dl/Peak level 900-1000 ng/dl) (n=125) |
| No Signs of Toxicity |
29 |
17 |
31 |
23 |
17 |
20 |
26 |
| Hypertension |
3 |
4 |
ـــــ |
4 |
1 |
1 |
4 |
| Tremors |
1 |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
1 |
| Facial Flushing |
ـــــ |
1 |
ـــــ |
1 |
ـــــ |
ـــــ |
ـــــ |
| Over growth of gums |
ـــــ |
ـــــ |
ـــــ |
1 |
ـــــ |
ـــــ |
ـــــ |
| Hirsutism |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
| Visual Impairment |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
1 |
ـــــ |
| Normal cyclosporine concentration (Trough level 150-200 ng/dl/Peak level 800-900 ng/dl) (n=151) |
| No Signs of Toxicity |
27 |
46 |
37 |
14 |
31 |
25 |
14 |
| Hypertension |
1 |
ـــــ |
2 |
ـــــ |
1 |
1 |
ـــــ |
| Tremors |
ـــــ |
1 |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
| Facial Flushing |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
1 |
ـــــ |
ـــــ |
| Over growth of gums |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
| Hirsutism |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
| Visual Impairment |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
ـــــ |
| Number and percentage of studied cases regarding toxic cyclosporine signs (n=102) |
| No Signs of Toxicity |
Hypertension |
Tremors |
Facial Flushing |
Gum Over growth |
Hirsutism |
Visual Impairment |
| 84 (82.7%) |
15 (14%) |
11(10%) |
5 (4%) |
1(0.9) |
1(0.9) |
3(2.9%) |
| Toxic Cyclosporin (Cs) Level |
11 |
8 |
4 |
1 |
1 |
2 |
| High normal Cs Level |
3 |
2 |
ـــــــــ |
ـــــــــ |
ـــــــــ |
1 |
| Normal Cs Level |
1 |
1 |
1 |
ـــــــــ |
ـــــــــ |
ـــــــــ |
