| GM |
Adjudin |
n |
|
7 days |
| 40 mg/kg |
Negative |
9(8) |
Frequency average of shifts (dB) |
8 ± 0.4 |
| OHC loss % in basal turn |
31 ± 0.3 |
| OHC loss % in apical turn |
10 ± 0.5 |
| 60 mg/kg |
Negative |
9(9) |
Frequency average of shifts (dB) |
33 ± 2 |
| OHC loss % in basal turn |
75 ± 1 |
| OHC loss % in apical turn |
52 ± 1 |
The frequency average of shifts was calculated by an average the threshold shift
in each tested frequency, the percentage value of OHC loss was calculated as
the result of lost OHCs divided by the total OHCs in the corresponding area. n =
sample size (survived animals). Apical turn is the region of basilar membrane from
0 to 2.4 mm (begin at apex); basal turn is the region of basilar membrane from 2.4
to 5.2 mm. |
