Figure 8: Proximal femur including the physis (hematoxylin and eosin stain). (A) Control rat. (B) Rat dosed for 6 months with LY2157299 had expansion of the physeal zones of maturation and hypertrophy, increased density and interconnectivity of the subphyseal primary and secondary spongiosa, and an orderly increase in the trabecular bone density.