| Receptor/
neurotransmitter |
Affinity ibogaine
(IC50, μM) |
Affinity noribogaine
(IC50, μM) |
Action in CNS |
Clinical effect |
| Serotonergic |
|
|
|
|
| 5-HT |
0.59 |
0.04 |
Reuptake blocker |
Nausea, vomiting |
| Opiodergic |
|
|
|
|
| μ-receptors |
11 |
0.16 |
Agonist |
Respiratory depression, bradycardia |
| κ1-receptor |
25 |
4.2 |
Partial agonist |
Miosis,diuresis |
| κ2-receptor |
23.8 |
92.3 |
Partial agonist |
Dysphoria |
| Glutaminergic |
|
|
|
|
| NMDA |
5.2 |
31.4 |
Channel blocker |
|
| AChE |
|
|
Inhibitor |
|
| Extracellular dopamine |
|
|
Decrease in dopamine levels |
Possibly leading to ataxia, tremors |
Abbreviations: 5-HT, serotonin; NMDA, N-methyl-D-aspartate; AChE, acetylcholinesterase; IC50, half maximal inhibitory concentration [6,8-10] |
