Drugs |
Exposure Time (min) |
DFIa |
Apoptotic Cellsb |
DNA Tailc ± SD |
ATENOLOL |
untreated |
9,71 |
27 |
3,67 ±1,37 |
15 |
26,05 |
39 |
78,54 ± 11,64 |
30 |
33,99 |
43 |
83,90 ± 15,41 |
45 |
24,60 |
36 |
76,36 ± 10,38 |
ATORVASTATIN |
untreated |
7,00 |
18 |
7,73 ± 1,40 |
15 |
57,00 |
63 |
17,64 ± 4,63 |
30 |
70,00 |
83 |
49,85 ± 12,20 |
45 |
65,00 |
69 |
18,87 ± 5,21 |
OFLOXACIN |
untreated |
12,49 |
12 |
8,31 ± 0,78 |
15 |
39,82 |
54 |
37,87 ± 6,40 |
30 |
41,90 |
69 |
73,79 ± 10,26 |
45 |
40,85 |
67 |
47,23 ± 8,43 |
SILDENAFIL CITRATE |
untreated |
13,33 |
19 |
3,42 ± 2,17 |
15 |
33,30 |
31 |
43,30 ± 12,74 |
30 |
40,00 |
35 |
48,64 ± 17,43 |
45 |
56,66 |
46 |
54,61 ± 11,65 |
GEMFIBROZIL |
untreated |
5,30 |
16 |
4,94 ± 1,97 |
15 |
8,96 |
21 |
17,94 ± 10,71 |
30 |
10,32 |
35 |
22,38 ± 11,07 |
45 |
13,57 |
39 |
33,14 ± 15,48 |
IBUPROFEN |
untreated |
3,31 |
20 |
4,94 ± 1,97 |
15 |
6,66 |
49 |
14,93 ± 3,47 |
30 |
9,55 |
36 |
65,45 ± 14,73 |
45 |
4,05 |
32 |
34,93 ± 13,63 |
CARBAMAZEPINE |
untreated |
11,31 |
19 |
5,18 ± 1,04 |
15 |
26,60 |
25 |
11,78± 4,91 |
30 |
34,37 |
33 |
13,03 ± 6,32 |
45’ |
45,49 |
39 |
13,90 ± 6,90 |
DICLOFENAC |
untreated |
13,31 |
19 |
6,17 ± 2,62 |
15 |
29,81 |
21 |
12,13 ± 5,57 |
30 |
41,89 |
33 |
14,12 ± 5,34 |
45 |
46,06 |
42 |
23,35 ± 4,29 |
BEZAFIBRATE |
untreated |
16,66 |
16 |
8,31 ± 0,78 |
15 |
20,00 |
21 |
11,51 ± 5,98 |
30 |
32,50 |
27 |
33,90 ± 11,51 |
45 |
40,85 |
38 |
55,30 ± 10,87 |
aDNA Fragmentation Index expressed in percentage as a result of the TUNEL test
bNumber of apoptotic cells expressed in percentage as a result of the Diffusion Assay
cDNA present in the tail of the comet expressed in percentage after the COMET Assay
SD = standard deviation |