Metalaxyl (mg /kg/day)

0

20

40

80

Total number of fetuses (litters) examineda

External

284 (27)

263 (26)

266 (27)

279 (28)b

Visceral

142 (27)

132 (26)

133 (27)

140 (28)

Skeletal

142(27)

131 (26)

133 (27)

139 (28)

Skeletal malformations

Absence of sacrum

0 (0)

8 (5)*

10 (6)*

20 (15)*

Ribs/fused/wavy/absence/small

0/0/0/0

10 (5)*/5(4)*/5(3)*/6(3)*

7 (4)*/10(8)*/12(10)*/12(10)*

12(10)*/15(15)*/15(12)*/20(19)*

Shortening of long bones

0 (0)

0 (0)

6 (5)*

10 (10)*

Absence of metatarsals/metacarpals

4 (2)/1 (1)

12 (7)/5 (5)

15 (12)*/ 11 (9)*

23 (19)*/21 (20)*

Absence of phalanges

5 (3)

13 (8)*

20 (17)*

26 (15)*

Skeletal variations

Poorly ossified interparietal

0 (0)

1 (1)

5 (5)*

17 (15)*

Poorly ossified thoracic centrum

0 (0)

4 (4)*

11 (8)*

20 (16)*

Cranial retardation

0 (0)

9 (6)*

12 (10)*

18 (15)*

Complete ossification of fetuses

0 (0)

2 (2)*

3 (2)*

4 (4)*

Total number of fetuses (%) with skeletal malformation and variations

6 (4)

45 (34)*

66 (50)**

102 (73)**

Total number of litters (%) with skeletal malformations and variations

4 (15)

26 (100)**

27 (100)**

28 (100)**