Table 1

Chemical	Daily dose, d (mg kg^-1)	Median tumor induction time, t (days)	Total dose, D (mg kg^-1)	n
4-DAST	3.4	250	850	3.0
	2.0	340	680
	1.0	407	407
	0.5	550	275
	0.28	607	170
	0.2	700	140
	0.1	900	90
DENA	9.6	101	963	2.3
	4.8	137	660
	2.4	192	460
	1.2	238	285
	0.6	355	213
	0.3	457	137
	0.15	609	91
	0.075	840	64

Table 1: Induction of ear-duct carcinomas in BDII rats by 4-DAST and of liver carcinomas by DENA, after Druckrey and Dischler [21], and Druckrey et al. [22].