Spearman correlations p-values (Spearman) Normalized mutual information B lymphocytes CD20 0.45 p<0.001 0.79 Macrophages CD68 0.21 0.0048 0.55 Mast cells CD117 0.27 p<0.001 0.32 The null hypothesis is that there is no correlation between each cell type and disease severity group.

Table 2: Statistical associations by means of the Spearman rank correlation test and the normalized mutual information.