Long Evans rat pups were treated with 50 μl i.p. injections of saline (vehicle) or 2.0 mg/kg ethanol in saline on postnatal days 2, 4, 6, and 8. On postnatal 19, rats (N=12/group) were subjected to 10 rotarod test trials in which speed of the rotating rod was incremented with each trial. Latency to fall was recorded. Data from Trials 1-3 (2-5 rpm), Trials 4-6 (5-7 rpm), or Trials 7-10 (8-10 rpm) were culled and analyzed using the Mann-Whitney test. Significant inter-group differences are shown in the panels.
Figure 1: Long-term effects of early postnatal binge ethanol exposure on rotarod motor performance.