| Parameters |
HCV patients
with HCC
(n=15) |
HCV patients
without HCC
(n=15) |
Healthy
Subjects
(n=15) |
P value |
| Age (years) |
51.27 ± 5.56 |
52.73 ± 7.23 |
50.93 ± 6.77 |
0.844 |
Gender:
- Male (%)
- Female (%) |
15 (100.0)
0 (0.0) |
15 (100.0)
0 (0.0) |
15 (100.0)
0 (0.0) |
|
| AST (U/L; mean ± SD) |
68.40 ± 30.38a b |
50.87 ± 25.11a |
20.13 ± 3.78 |
<0.0001 |
| ALT (U/L; mean ± SD) |
71.47 ± 29.44a b |
40.53 ± 19.18a |
20.40 ± 4.55 |
<0.0001 |
| GGT (U/L; mean ± SD) |
102.27 ± 80.4 a b |
43.47 ± 21.62 |
20.93 ± 3.20 |
0.0001 |
| Serum albumin (g/dl; mean ± SD) |
3.53 ± 0.20a |
3.49 ± 0.18a |
4.60 ± 0.46 |
<0.0001 |
| Serum bilirubin (mg/dl; mean ± SD) |
1.08 ± 0.13 a |
1.05 ± 0.23 a |
0.64 ± 0.16 |
<0.0001 |
| INR (mean ± SD) |
1.19 ± 0.08 a |
1.25 ± 0.13 a |
1.07 ± 0.04 |
<0.0001 |
| AFP (ng/ml; mean ± SD) |
1302.36 ± 1890.19a b |
6.00 ± 2.35 |
4.60 ±1.60 |
0.002 |
Child-Pugh class:
- Class A (%)
- Class B (%) |
11 (73.3)
4 (26.7) |
7 (46.7)
8 (53.3) |
NA |
0.132 |
| MELD score |
7.13 ± 1.19 |
8.40 ± 1.96 |
NA |
0.119 |
| Serum MIP-1a (pg/ml) |
27.33 ± 4.58a b |
8.67 ± 6.11a |
1.67 ± 2.44 |
<0.0001 |
AST: Aspartate Amino Transferase; ALT: Alanine Amino Transferase; GGT: Gamma Glutamyl Transpeptidase; INR: International Normalized Ratio; AFP: Alpha-Fetoprotein; MELD: Model for End-Stage Liver Disease; MIP-1α: Macrophage Inflammatory Protein-1α