Mutation HBeAg-positive group HBeAg-negative group
HCC (n=70)       CH (n=74) P value HCC (n=32)       CH (n=31) P value
T1762/A1764  46  40  0.891   20  14 0.634
V1753/ T1762/A1764 (65.7%) (54.1%)   (62.5%) (45.2%) 0.062
T1762/A1764/ A1768  10    0.027 2 (6.3%)   0.961
V1753/ (14.3%)* 3 (4.1%)  0.031 1 (3.1%)  1  
T1762/A1764/A1768 6    0.041  0 (0%)  (3.2%)  
  (8.6%)* 2 (2.7%)     1  
  3       (3.2%)  
  (4.3%)*  1 (1.4%)     0 (0%)   
*HCC vs.CH, P < 0.05 (Yates corrected chi-square). Significant data are shown in bold
Table 4: Accumulation of BCP mutations among patients with HCC and CH in context of HBeAg.