S no. Lesion No. Of  total cases No. Of positive cases Cumulative score
Weakly reactive Moderately reactive Highly reactive Mean ± sd
0-3 7-apr >8
Group I Plemorphic adenoma            
Benign 8 8 3 2 3 5.88 ± 3.271
Malignant Peripheral mucoepidermoid carcinoma 5 5 - - 5 10.4  ± 3.05
Central mucoepidermoid carcinoma 4 4 - 3 1 6.50 ± 3.786
Adenocarcinoma nos 2 2 - 1 1 6 ± 2.828
               PLGA 1 1 1 - - 2
Total 12 12 1 4 7 7.66 ± 3.91
A total of 20 cases formed the study group out of which Group I (Benign) comprising of 8 cases and group II (Malignant) comprising of 12 cases were each immunohistochemically stained for podoplanin. All 8 cases of group I were positive and expression varied from weak to intense with 3 cases showing strong expression. In group II, all 12 cases were positive and the expression varied from weak to high with 7 cases showing strong positive podoplanin expression. Overall, malignant tumours showed a more intense podoplanin expression compared to benign tumours.
Table 2: Cases showing strong podoplanin immune expression.