Figure 2: Possible interventions for mitochondrial rejuvenation. Exercise serves to improve mitochondrial function and reduce pathologies even in mice with inborn mitochondrial dysfunction. Calorie restriction (CR), a dietary intervention that increases longevity in a variety of organisms, improves mitochondrial function. Induced pluripotent stem (iPS) cell technology “reset” the clock in the mitochondrial compartment. Improving mitochondria function may have benefits at the cellular and organismal levels, leading to improved health and potentially increased longevity.