Study Target miRNA Expression Level CRC VS. HC Sample Size ( n ) For CRC Detection Internal Control Reference CRC Polyps/ Adenoma HC Sensitivity /Specificity Wu et al. [72] miR-92a miR-21 Up-regulated 88 57 (polyps) 101 71.6/73.3 56.1/73.3 (Forpolyps) U6 snRNA [72] Li et al. [74] miR-143 miR-145 Down-regulated 38   13   miR-16 [74] Kalimutho et al. [69] miR144 Up-regulated 35   40   miR-378 [69] Link et al. [71] miR-21 miR-106a Up-regulated 10 9 (adenoma) 8   miR-16/ miR-26b [71] Koga et al. [73] miR-17-92 cluster miR-135 Up-regulated 197   119 69.5/81.5 46.2/95 U6 snRNA [73] Ahmed et al. [66] 14 types miRNAs Up-regulated miR-21,-106a, -96, -203, -20a, -326 -92 Down-regulated miR-320, -126, -143, -484-5p, -16, -145 -125b 15   5   Total RNA/ 18S rRNA [66] Abbreviations: CRC: Colorectal Cancer; miRNA: microRNA; snRNA: small nuclear RNA; HC: Healthy Control.

Table 1: Fecal-based miRNAs as potential diagnostic markers for CRC.