Amsterdam Criteria I: At least 3 relatives with CRC and meeting the following criteria: -    1 affected individual should be familiar of 1st degree of the other 2. -    At least 2 successive generations must be affected -    At least 1 case of CRC diagnosed before the age 50 -    Familial adenomatous polyposis has been excluded Amsterdam Criteria II: At least 3 relatives with CRC, endometrial, small bowel, ureter or renal pelvis cancer and meeting following criteria: -    1 affected individual should be familiar of 1st degree of the other 2. -     At least 2 successive generations must be affected -    At least 1 case of CRC diagnosed before the age 50 -    Familial adenomatous polyposis has been excluded Bethesda Guidelines: At least 1 of the following criteria required: -    CRC diagnosed before the age 50 -    Synchronic or metachronic presence of CRC and/or another neoplasm associated to Lynch syndrome, independently of the age of diagnosis -    CRC diagnosed before the age 60 and with histology showing microsatellites instability -    CRC diagnosed in a patient with > 1 first degree relative with a tumour associated to Lynch syndrome, with at least 1 tumour diagnosed before the age 50 -    CRC diagnosed in a patient and > 2 relatives of 1st or 2nd degree with tumours associated to Lynch syndrome, independently of the age of diagnosis

Table 2: Amsterdam Criteria I and II, and Bethesda Guidelines