Risk Factors

Reference

IBD

Results

Extensive Colitis

[8]

UC

Relative risk of neoplasia
RR 1.7 (95% Cl, 0.8-3.2) in ulcerative proctitis
RR 2.8 (95% Cl, 1.6-4.4) in left-sided colitis
RR 14.8 (95% Cl, 11.4-18.9) in extensive colitis

[53]

UC, CD

Relative risk of neoplasia
RR 19.2, (95% Cl, 12.9-27.5) p<0.001 in UC
RR 18.2, (95% Cl, 7.8-35.8) p<0.001 in Crohn’s colitis

Histological Inflammation

[46]

UC

OR 6.98 (95% Cl, 2.42-20.16) p<0.001 for neoplasia

[47]

UC

HR 1.4 (95% Cl, 0.9-2.3) for any neoplasia
HR 3.0 (95% Cl, 1.4-6.3) for advanced neoplasia

Backwash lleitis

[48]

UC

OR 19.36 (95% Cl, 4.6-135.8) p<0.001 for neoplasia

Age at Diagnosis

[8]

CD

SIR 12.025 (95% Cl, 3.1-23.2) for neoplasia with IBD diagnosis <30 yo

[8]

UC

SIR 118.3 (95% Cl, 63.0-202.3) for neoplasia with UC diagnosis <15 yo
SIR 16.5 (95% Cl, 10.2-25.2) for neoplasia with UC diagnosis 15-29 yo

CRC Family History

[54]

UC, CD

Relative risk of neoplasia
RR 2.0 (95% Cl, 1.0-4.1) in UC
RR 3.7 (95% Cl, 1.4-9.4) in CD

[55]

UC

OR 2.33 (95% Cl, 1.06-5.14) p=0.03 for neoplasia

Concomitant PSC

[49]

UC

Adjusted RR 3.15 (95% Cl, 1.37-7.27) for neplasia or dysplasia

[50]

UC

Adjusted RR 10.4 (95% Cl, 4.1-26.1) for neplasia or dysplasia