Figure 2: Effects of the peptides of Hsp-65 to proinflammatory cytokine production. a. IL-12 was highly produced by PBMCs from active BD patients without stimulation (Control). IL-12 production from BD patients was significantly reduced by incubation with LO1, LO2, LO3, III-b and UK (*). On the other hand, IL-12 production from PBMCs of HIs was all elevated by these peptides (red points). b. LO1, III-a and III-b significantly reduced IL-8 production from PBMCs of BD patients (*) in comparison with the control level of cytokine production. On the other hand, IL-8 production was accelerated from PBMCs of HIs by these peptides.