Figure 2: Positions of the 28 complete ORFs of CVB in the plot of the first two major axes by correspondence analysis (COA) of relative synonymous codon usage (RSCU) values. The first and second axes account for 32.31 % and 12.52 % of the total variation, respectively. The CVB ORFs are divided according to their genotype, genotype B1 strains are indicated by a black diamond (◊), genotype B2 by a white square (□), genotype B3 by a black square (■), genotype B4 by a white diamond (◊), genotype B5 by a black triangle (▲) and genotype B6 by gray circle. CVB strains known to be associated with diabetes (DQ480420, genotype B4) or myocarditis (M16572, genotype B3) are shown by a black (●) and a white (○) circle, respectively. Strain AY875692 (genotype B5), isolated from a CSF sample, is shown by a white triangle (Δ).