Early Participants (n=368) With follow-up (n=142) Without follow-up (n=226) p† unadjusted p† adjusted Mean age (years) 47 ± 7.87 43 ± 7.44 <0.001 - Male sex 116 (82%) 180 (80%) 0.63 - Education             low 21 (15%) 16 (7%) 0.06 0.33 midlevel 38 (27%) 56 (25%) high 83 (58%) 154 (68%) History of CVD 6 (4%) 4 (2%) 0.16 0.39 Current medication therapy for hypertension 11 (8%) 18 (8%) 0.94 0.36 Current statin use 7 (5%) 12 (5%) 0.87 0.25 Current diabetes medication 2 (1%) 5 (2%) 0.58 0.39 Physical activity             Adherence to Adherence to Dutch Standard for Healthy Physical Activity* 34 (24%) 48 (21%) 0.54 0.95 Total amount of moderate physical activity ≥150 minutes/week 65 (46%) 108 (48%) 0.71 0.57 Nutrition             Fruit : consumption of ≥ 2 pieces/day 26 (18%) 47 (21%) 0.44 0.91 Vegetables: consumption of ≥ 3 serving spoons (≥ 150 grams) per day 61 (43%) 96 (43%) 0.53 0.52 Smoking             Daily tobacco smoking 23 (16%) 36 (16%) 0.95 0.77 Alcohol consumption             men drinking >21 units/week or women drinking >14 units/week 8 (6%) 17 (8%) 0.48 0.21 Body Mass Index (kg/m2) 25.4 ± 3.41 25.3 ± 3.61 0.85 0.83 BMI ≥ 25 69 (49%) 108 (48%) 0.88 0.81 Waist circumference (cm) 93.0 ± 11.01 92.5 ± 10.31 0.67 0.90 Waist circumference, men >102 cm, women >88 cm 32 (23%) 50 (22%) 0.93 0.95 Systolic Blood Pressure (mmHg) 135.0 ± 17.18 131.5 ± 15.58 0.04 0.17 Diastolic Blood Pressure (mmHg) 81.8 ± 11.05 79.7 ± 10.47 0.07 0.26 Blood pressure ≥ 140/90 (mmHg) 55 (39%) 66 (29%) 0.06 0.26 Total cholesterol (mmol/l) 5.7 ± 1.04 5.6 ± 0.92 0.12 0.42 HDL (mmol/l) 1.4 ± 0.34 1.4 ± 0.37 0.48 0.29 LDL (mmol/l) 3.7 ± 0.90 3.5 ± 0.86 0.08 0.25 Triglycerides (mmol/l) 1.6 ± 0.98 1.5 ± 0.85 0.26 0.41 Framingham 10 year CVD risk score (%) 10.7 ± 8.84 7.7 ± 6.66 <0.001 0.19 Values are expressed as mean ± SD and number of participants (%).

Table 1: Baseline characteristics of 368 early participants in the HRA program by follow-up status. *For adults at least half an hour of moderately intensive physical activity on at least five days a week is recommended. p†: P for difference between early participants with follow-up and without follow-up. Analyses for differences in baseline systolic and diastolic blood pressure, body mass index, waist circumference, total cholesterol, HDL, LDL, triglycerides and Framingham scores were adjusted for age and sex, using linear regression with the variable of interest as dependent variable and age, sex and attending for follow-up measurements as covariates. Analyses for differences in history of CVD, current medication for hypertension, current statin use, current diabetes medication, current smoking and blood pressure ≥ 140/90 mmHg were adjusted for age and sex, using logistic regression with the variable of interest as dependent variable and age, sex and attending for follow-up measurements as covariates.