Figure 4: Photomicrographs of cross sections in the liver of the cisplatinum and vitamin E treated group showing: (a) Congestion of the central vein (C), intracytoplasmic vacuolations (V) and kupffer’s cells containing hemosiderin granules (arrows). (H & E x 400) (b) Intranuclear vacuolations (blue V), intracytoplasmic vacuolations (red V). Note the presence of karryorehxis (kr) and pleomorphism of the hepatic cells. (H & E x 1000) (c) Intracytoplasmic vacuolations (V), degenerated nucleus (arrow) with margination of the nucleoli (M). (Toludine blue x 1000)