Figure 5: Electron photomicrographs of cross sections in the liver of (a): The control group showing euchromatic nucleus (N) with nucleolus (nu), normal mitochondria (M) and rough endoplasmic reticulum (rER). (Uranyl acetate x 6000) (b) The cisplatinum treated group showing multiple intracytoplasmic vacuoles of variable sizes (V) and some of them indenting the hepatic nucleus (arrows). Note the degenerated nuclei with marginated nucleolus (N1) and irregular nuclear membrane (N2). (Uranyl acetate x 5000) (c) The cisplatinum and vitamin E treated group showing degenerated nuclei (N) and sinusoidal congestion (C) (Uranyl acetate x 1500) (d) The cisplatinum and vitamin E treated group showing rarified cytoplasm (r). Note the presence of a degenerated nucleus (N) with margination of the nucleolus. (Uranyl acetate x 3000)